Before attempting runs with The Lost, unlock any items that may be helpful for The Lost. Powerful item combinations are often necessary for a successful run. Although possible, it is extremely difficult to finish a full playthrough without getting hit at all. Therefore, he needs to be played with extreme care.

don't rule out devil deals sure the meta rn is angel rooms but since you can't get more than 1 item out of an angel room then going for devil deals might be a good callĪlso there's a couple of glitches you can abuse if you find them, e.g. The Lost has no health, dying by any damage taken. sure, you're gonna have mediocre half-baked stats, but all the extra health can help you survive the million years it's gonna take you to kill the endgame bosses have patience because the only upside to tainted lazarus is that he can potentially have double the max health of everyone else. when dead lazarus is strong enough, start giving damage ups to alive lazarus and vice versa to balance them out

Rebirth was released for Microsoft Windows, OS X, Linux, PlayStation 4, and PlayStation Vita in November 2014, and for Xbox One, New Nintendo 3DS, and Wii U in July 2015. other things go to alive lazarus, but you mainly want to look for other ways of dealing damage which aren't damage ups, such as familiars, tear modifiers or stuff that gives you flat damage like blood clot The Binding of Isaac: Rebirth is an indie roguelike video game designed by Edmund McMillen and developed and published by Nicalis. give damage ups to dead lazarus at the start, he has a higher damage multiplier and you want to use him to fight all the bosses I'd just recommend waiting or modding tainted lazarus, they left him unfinished so who cares really, not to mention the fact a bunch of items just don't work properly with him (Abyss, Bumbo and other bum familiars to name some) but if you're dying to do it legit then here's how i went about it: While the original game has its own charm, The Binding of Isaac: Rebirth is superior in almost. Its a truly addictive gameplay experience that tests your ability and strategy, but its loads of fun. Originally posted by Dead Rift:How about tainted jacob with mega satan? He pretty much destroys esasu immediately well you cant progress the mega satan fight with esau alive anyway so you have to do it in the lost form regardless The Binding of Isaac: Rebirth offers dozens of new bosses, hundreds of new rooms, and a countless number of power-up combinations.

Binding of isaac rebirth strategy